Basic bismuth salt of guaiacol carboxylic acid



Patented Jan. 6, 1925.

" STATES PATENT OFFICE.

HANS HAT-IL AND WALTER,KROPP, OF ELBERFELD, GERMANY, ASSIGNORS TO FARBEN- FABRIKEN VORM. FRIEDR. BAYER AND 00., OF LEVERKUSEN, NEAR- COLOGNE-ON- TI-IE-RHINE, GERMANY.

BASIC BISMUTI-I SALT OF GUAIACOL CARIBOXYLIC ACID.

No Drawing.

To all whom it may concern:

Be it known that We, HANS HAHL and lVALTER KnoPP, citizens of Germany, residing at Elberfeld, in the State of Prussia,

5 Germany, have invented new and useful Improvements in a Basic Bismuth Salt of Guaiacol Carbonylic Acid, of which the following is a specification.

Our invention concerns the production of the hitherto unknown basic bismuth salt of guaiacol carboxylic acid having most probably the following formula:

OCHa

The new product has proved to be a valuable remedy against luetic diseases. Its oily emulsions are used for subcutaneous injections. The anaesthetic properties of the guaiacol carboxylic acid appeases the pain of injection. The new product contains about 53-56 per cent bismuth and is a whitish-yellow powder insoluble in water and organic solvents. It can be obtained by treating the guaiacol carboxylic acid with bismuth oxide.

In order to illustrate our invention, the following example is given G 200 parts by weight of powdered bismuth nitrate are dissolved in 150-200 parts by weight of a 30 per cent acetic acid. It is Application filed April 15, 1924. Serial No. 706,749.

filtered and the filtrate is rendered slightly alkaline with caustic soda solution. Subsequently the precipitate is treated with water until it is neutral; it is then stirred up 2 canon O COO-Bi being a whitish yellow powder insoluble in water and in the usual organic solvents, being a valuable anti-syphilitic for sub cutaneous use in an oil emulsion, substantially as described.

In. testimony whereof we have hereunto set our hands.

HANS HAHL. WALTER KROPP. 

